Cyanamidnatrium → 5-[4-(Tetrahydropyran-4-yl)-phenoxymethyl]-4,5-dihydro-oxazol-2-ylamine

HRID 237740Notes

Reaction equation

[O:1]1[CH2:3][CH:2]1[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:8][CH:7]=1.[N:18]#[C:19][NH2:20].[Na]>>[O:15]1[CH2:16][CH2:17][CH:12]([C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH:2]3[O:1][C:19]([NH2:20])=[N:18][CH2:3]3)=[CH:7][CH:8]=2)[CH2:13][CH2:14]1

Participants

Reactant 2

HCID 57375518Cyanamidnatrium

HCID 866402314-[4-(Oxiran-2-ylmethoxy)phenyl]oxane

Product 1

HCID 685238905-[4-(Tetrahydropyran-4-yl)-phenoxymethyl]-4,5-dihydro-oxazol-2-ylamine

Procedure

The title compound was prepared from 4-(4-oxiranylmethoxy-phenyl)-tetrahydropyran and sodium hydrogen cyanamide according to the procedures employed for the preparation of the compound in Step 2 of Example 1.

Workup

customemployed for the preparation of the compound in Step 2 of Example 1

Sources & evidence

ORD record: ord-e6c98fc2a36a47f9b90084ce59ec95ca
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08642603B2

Reaction notes

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