1,2,2,6,6-Pentamethyl-4-(4-oxiranylmethoxy-phenyl)-piperidine → 5-[4-(1,2,2,6,6-Pentamethyl-piperidin-4-yl)-phenoxymethyl]-4,5-dihydro-oxazol-2-ylamine

HRID 237748Notes

Reaction equation

HRID 237748 reaction equation
[CH3:1][N:2]1[C:7]([CH3:9])([CH3:8])[CH2:6][CH:5]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][CH:18]3[CH2:20][O:19]3)=[CH:12][CH:11]=2)[CH2:4][C:3]1([CH3:22])[CH3:21].[N:23]#[C:24][NH2:25].[Na]>>[CH3:1][N:2]1[C:3]([CH3:21])([CH3:22])[CH2:4][CH:5]([C:10]2[CH:11]=[CH:12][C:13]([O:16][CH2:17][CH:18]3[O:19][C:24]([NH2:25])=[N:23][CH2:20]3)=[CH:14][CH:15]=2)[CH2:6][C:7]1([CH3:8])[CH3:9]

Participants

3

Reactant 2

HCID 196012081,2,2,6,6-Pentamethyl-4-(4-oxiranylmethoxy-phenyl)-piperidineHCID 57375518Cyanamidnatrium

Product 1

HCID 685242135-[4-(1,2,2,6,6-Pentamethyl-piperidin-4-yl)-phenoxymethyl]-4,5-dihydro-oxazol-2-ylamine

Procedure

The title compound was prepared from 1,2,2,6,6-pentamethyl-4-(4-oxiranylmethoxy-phenyl)-piperidine and sodium hydrogen cyanamide according to the procedures employed for the preparation of the compound in Step 2 of Example 1.

Workup

  1. customemployed for the preparation of the compound in Step 2 of Example 1

Sources & evidence

ORD record
ord-b33e2c646de84a4080ab04aea894d554
Source dataset
uspto-grants-2014_02
Patent number
US08642603B2

Reaction notes

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