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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 237748Generated: October 30, 2026

1,2,2,6,6-Pentamethyl-4-(4-oxiranylmethoxy-phenyl)-piperidine → 5-[4-(1,2,2,6,6-Pentamethyl-piperidin-4-yl)-phenoxymethyl]-4,5-dihydro-oxazol-2-ylamine

https://huagongshe.com/reaction/237748

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2,2,6,6-Pentamethyl-4-(4-oxiranylmethoxy-phenyl)-piperidineHCID 19601208—
ReactantCyanamidnatriumHCID 57375518—
Product5-[4-(1,2,2,6,6-Pentamethyl-piperidin-4-yl)-phenoxymethyl]-4,5-dihydro-oxazol-2-ylamineHCID 68524213—

Reaction Steps

The title compound was prepared from 1,2,2,6,6-pentamethyl-4-(4-oxiranylmethoxy-phenyl)-piperidine and sodium hydrogen cyanamide according to the procedures employed for the preparation of the compound in Step 2 of Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08642603B2
Source datasetuspto-grants-2014_02
ORD IDord-b33e2c646de84a4080ab04aea894d554
Source noteuspto-grants-2014_02