反应详情

A solution of 2-{4-[5-(cyclopropyl-methyl-amino)-8,8-dimethyl-5,6,7,8-tetrahydro-naphthalen-2-ylethynyl]-phenyl}-2-methyl-propionic acid methyl ester (Intermediate 170, 0.08 g, 0.19 mmol) in methanol (3 mL) and tetrahydrofuran (3 mL) was treated with a 2M solution of sodium hydroxide (2 mL, 4 mmol) and the resulting reaction mixture was refluxed overnight. The volatiles were evaporated in vacuo and the residue was diluted with saturated aqueous ammonium chloride solution and extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title product (0.07 g, ˜100%).

1. customthe resulting reaction mixture
2. temperaturewas refluxed overnight
3. customThe volatiles were evaporated in vacuo
4. additionthe residue was diluted with saturated aqueous ammonium chloride solution
5. extractionextracted with ethyl acetate
6. dry with materialThe organic phase was dried over anhydrous magnesium sulfate
7. filtrationfiltered
8. customevaporated in vacuo