HCID 21107234, compound → HCID 21107251, compound

HRID 2377502Notes

Reaction equation

HRID 2377502 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[C:11]([CH:13]=[CH2:14])[CH:12]=1)[C:9](=[O:15])[CH2:8][CH2:7][C:6]2([CH3:17])[CH3:16]>C(OCC)(=O)C.[Pd]>[CH2:13]([C:11]1[CH:12]=[C:3]([O:2][CH3:1])[CH:4]=[C:5]2[C:10]=1[C:9](=[O:15])[CH2:8][CH2:7][C:6]2([CH3:16])[CH3:17])[CH3:14]

Participants

4

Reactant 1

HCID 21107234HCID 21107234, compound2×

Product 1

HCID 21107251HCID 21107251, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 8-vinyl-6-methoxy-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one (Intermediate 155, 1.12 g, 4.86 mmol) in ethyl acetate (10 mL) was treated with 10% palladium on carbon (100 mg) and the resulting reaction mixture was stirred under an atmosphere of hydrogen overnight. The reaction mixture was filtered over a bed of celite and the filtrate was evaporated to afford the title product (1.1 g, 98%).

Workup

  1. customthe resulting reaction mixture
  2. filtrationThe reaction mixture was filtered over a bed of celite
  3. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-675d5583de1c4fdd9eba652c6f52909c
Source dataset
uspto-grants-2008_12
Patent number
US07468391B2

Reaction notes

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