Hydrogen Peroxide → 5-Fluoro-3-pyridinol N-oxide

Temperature

70 °C

A solution of 1.5 g (13.26 mmol) of 5-fluoro-3-pyridinol in 8 ml of acetic acid is heated to 70° C. and 1.25 ml (14.6 mmol) of 35% hydrogen peroxide are added gradually. The reaction mixture is stirred for 15 hours at 70° C. and then concentrated under reduced pressure; 50 ml of cold water are added to the evaporation residue and the mixture is stirred for 1 hour. The precipitate obtained is filtered off, rinsed with water and with a minimum amount of cold ethyl acetate on the filter and then dried to give 930 mg of the expected product in the form of a white powder (yield=55%).

1. concentrationconcentrated under reduced pressure
2. addition50 ml of cold water are added to the evaporation residue
3. stirringthe mixture is stirred for 1 hour
4. customThe precipitate obtained
5. filtrationis filtered off
6. washrinsed with water and with a minimum amount of cold ethyl acetate on the
7. filtrationfilter
8. customdried

ORD record

ord-ee6bc25e092a404381519232f7ccdcc1

Source dataset

uspto-grants-2008_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07470671B2