Hydrochloric Acid → HCID 12462819, compound

HRID 2377587Notes

Reaction equation

HRID 2377587 reaction equation
[CH3:1][O:2][C:3](=[O:16])[CH:4]([C:8]1[CH:13]=[CH:12][C:11](Cl)=[C:10](Cl)[CH:9]=1)[CH2:5][CH:6]=[O:7].COC(=O)CC1C=CC([F:27])=CC=1.COC(OC)CBr.Cl>>[CH3:1][O:2][C:3](=[O:16])[CH:4]([C:8]1[CH:13]=[CH:12][C:11]([F:27])=[CH:10][CH:9]=1)[CH2:5][CH:6]=[O:7]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 816722-Bromo-1,1-dimethoxyethaneHCID 2733233Methyl 2-(4-fluorophenyl)acetateHCID 598565392-(3,4-Dichloro-phenyl)-4-oxo-butyric acid methyl ester

Product 1

HCID 12462819HCID 12462819, compound

Procedure

In analogy to the procedure described for the synthesis of 2-(3,4-Dichloro-phenyl)-4-oxo-butyric acid methyl ester (example 2, step 1) the title compounds was prepared from 4-fluoro-phenyl-acetic acid methyl ester (commercially available), and bromoacetaldehyde dimethylacetal and subsequent treatment with HCl aq. MS (m/e): 209.3 (MH−).

Sources & evidence

ORD record
ord-ef71e7ebfab74cdb9ff5bf96c731d6c5
Source dataset
uspto-grants-2008_12
Patent number
US07470684B2

Reaction notes

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