反应详情

温度

50 °C

1-(4-Benzyloxy-phenyl)-3,3-dimethyl-cyclohexanol (5.08 g, 16.4 mmol) was dissolved in EtOH (80 mL) after which concentrated hydrochloric acid (8 mL) was added. This mixture was stirred at 50° C. for 1.5 hours. The solvent was removed under reduced pressure. Water (15 mL) was added. The mixture was basified with aqueous ammonia and extracted three times with EtOAc. The organic phase was dried and concentrated to provide the title compound as a yellow solid 4.43 g as a mixture of isomers.

1. additionwas added
2. customThe solvent was removed under reduced pressure
3. additionWater (15 mL) was added
4. extractionextracted three times with EtOAc
5. customThe organic phase was dried
6. concentrationconcentrated