Hydrochloric Acid → HCID 28804660, compound

HRID 2377762Notes

Reaction equation

HRID 2377762 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH2:17][OH:18])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([Br:16])[CH:11]=1)(C)(C)C.Cl>CO.O1CCOCC1>[NH2:7][C@@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([Br:16])[CH:11]=1)[CH2:17][OH:18]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58666623468740-94-5

Product 1

HCID 28804660HCID 28804660, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of (S)-[2-(3-bromo-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester (400 mg, 1.21 mmol) in methanol (30 mL) was added 4 M HCl in dioxane (2 mL, excess). The reaction mixture was stirred at room temperature for 14 h. After concentration in vacuo, the residue was used for the next step without purification. LCMS (M+H)+ m/z 230 (t=0.78 min.)

Workup

  1. concentrationAfter concentration in vacuo
  2. customthe residue was used for the next step without purification
  3. customLCMS (M+H)+ m/z 230 (t=0.78 min.)

Sources & evidence

ORD record
ord-c4505e1518444c9489ac35858497daf3
Source dataset
uspto-grants-2008_12
Patent number
US07470696B2

Reaction notes

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