Stannous Chloride → 2-Amino-5-fluorobenzonitrile

HRID 2377822Notes

Reaction equation

HRID 2377822 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]#[N:12])([O-])=O.Cl[Sn]Cl>Cl>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]#[N:12]

Participants

4

Reactant 2

HCID 24479Stannous ChlorideHCID 37564675-Fluoro-2-nitrobenzonitrile

Product 1

HCID 27377042-Amino-5-fluorobenzonitrile

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The title compound was synthesized from commercially available 2-nitro-5-fluorobenzenecarbonitrile via reduction with SnCl2 in concentrated HCl as previously described in the following reference which is herein incorporated by reference in its entirety for all purposes as if fully set forth herein: Hunziker, F. et al. Eur. J. Med. Chem., Chim. Ther. 1981, 16(5), 391. GC/MS m/z: 136.1 (M+, 100%), Rt 8.87 minutes.

Sources & evidence

ORD record
ord-82cd11b6095e4c989100fbb664de1124
Source dataset
uspto-grants-2008_12
Patent number
US07470709B2

Reaction notes

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