4-Ethyl-2-(4-iodo-2-methoxy-pyridin-3-yl)-5-phenyl-imidazol-1-ol → 5-(4-Bromo-phenyl)-2-(4-iodo-2-methoxy-pyridin-3-yl)-imidazol-1-ol

HRID 2377967Notes

Reaction equation

HRID 2377967 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH:9]=[N:10]O)=[CH:4][CH:3]=1.C(C1N=[C:17]([C:27]2[C:28]([O:34][CH3:35])=[N:29][CH:30]=[CH:31][C:32]=2[I:33])[N:18]([OH:26])C=1C1C=CC=CC=1)C>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:18]([OH:26])[C:17]([C:27]3[C:28]([O:34][CH3:35])=[N:29][CH:30]=[CH:31][C:32]=3[I:33])=[N:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 598575774-Ethyl-2-(4-iodo-2-methoxy-pyridin-3-yl)-5-phenyl-imidazol-1-olHCID 72814957(4-Bromo-phenyl)-oxo-acetaldehyde oxime

Product 1

HCID 598575605-(4-Bromo-phenyl)-2-(4-iodo-2-methoxy-pyridin-3-yl)-imidazol-1-olYield 18%

Procedure

(4-Bromo-phenyl)-oxo-acetaldehyde oxime (0.242 g, 1.06 mmol) was reacted as described for the synthesis of 4-ethyl-2-(4-iodo-2-methoxy-pyridin-3-yl)-5-phenyl-imidazol-1-ol and gave the title material (0.090 g, 18%). LCMS (+ESI, M+H+) m/z 472, 474.

Sources & evidence

ORD record
ord-cac180b68e4f4afda0a19b51b086dfc1
Source dataset
uspto-grants-2008_12
Patent number
US07470713B2

Reaction notes

Loading…