4-Ethyl-2-(4-iodo-2-methoxy-pyridin-3-yl)-5-phenyl-imidazol-1-ol → 2-(4-Iodo-2-methoxy-pyridin-3-yl)-5-(4-morpholin-4-yl-phenyl)-imidazol-1-ol

HRID 2377968Notes

Reaction equation

HRID 2377968 reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13](=O)[CH:14]=[N:15]O)=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(C1N=[C:22]([C:32]2[C:33]([O:39][CH3:40])=[N:34][CH:35]=[CH:36][C:37]=2[I:38])[N:23]([OH:31])C=1C1C=CC=CC=1)C>>[I:38][C:37]1[CH:36]=[CH:35][N:34]=[C:33]([O:39][CH3:40])[C:32]=1[C:22]1[N:23]([OH:31])[C:13]([C:10]2[CH:9]=[CH:8][C:7]([N:1]3[CH2:2][CH2:3][O:4][CH2:5][CH2:6]3)=[CH:12][CH:11]=2)=[CH:14][N:15]=1

Participants

3

Reactant 2

HCID 598575774-Ethyl-2-(4-iodo-2-methoxy-pyridin-3-yl)-5-phenyl-imidazol-1-olHCID 72579574(4-Morpholin-4-yl-phenyl)-oxo-acetaldehyde oxime

Product 1

HCID 598575612-(4-Iodo-2-methoxy-pyridin-3-yl)-5-(4-morpholin-4-yl-phenyl)-imidazol-1-olYield 22%

Procedure

(4-Morpholin-4-yl-phenyl)-oxo-acetaldehyde oxime (0.111 g, 0.474 mmol) was reacted as described for the synthesis of 4-ethyl-2-(4-iodo-2-methoxy-pyridin-3-yl)-5-phenyl-imidazol-1-ol and afforded the title material (0.049 g, 22%).

Sources & evidence

ORD record
ord-7e867d1ee9344ddf92915a3deaa65385
Source dataset
uspto-grants-2008_12
Patent number
US07470713B2

Reaction notes

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