反应详情

A stirred solution of tert-butyl 2-(4-iodo-2-methoxypyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylate (0.047 g, 0.1131 mmol) in dichloromethane (0.8 mL) was added trifluoroacetic acid (0.6 mL) and the reaction was stirred at room temperature overnight. The solvent was evaporated after adding toluene (1 mL) and the residue was purified on Prep HPLC (trifluoroacetic acid/acetonitrile/water) to give the title material (0.039 g, 96%). 1H NMR (400 MHz, MeOH-d4) δ (ppm): 2.70 (s, 3H) 3.97 (s, 3H) 7.70 (d, J=5.56 Hz, 1H) 8.11 (d, J=5.56 Hz, 1H).

1. customThe solvent was evaporated
2. additionafter adding toluene (1 mL)
3. customthe residue was purified on Prep HPLC (trifluoroacetic acid/acetonitrile/water)