Diethyl cyclopropane-1,1-dicarboxylate → HCID 68955591, compound

HRID 2378073Notes

Reaction equation

HRID 2378073 reaction equation
C(OC(C1(C(OCC)=O)CC1)=O)C.[CH2:14]([O:16][C:17]([C:19]1([C:22]2(O)[O:26][N:25]=[C:24]([C:27]3[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=3)[CH:23]2[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH2:21][CH2:20]1)=[O:18])[CH3:15]>>[CH2:14]([O:16][C:17]([C:19]1([C:22]2[O:26][N:25]=[C:24]([C:27]3[CH:28]=[CH:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=3)[C:23]=2[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH2:20][CH2:21]1)=[O:18])[CH3:15]

Participants

3

Reactant 2

HCID 73790Diethyl cyclopropane-1,1-dicarboxylateHCID 68956981HCID 68956981, compound

Product 1

HCID 68955591HCID 68955591, compound

Procedure

The title compound is prepared using the experimental procedure described in Example 147B except cyclopropane-1,1-dicarboxylic acid diethyl ester is used instead of cyclopropane-1,1-dicarboxylic acid dimethyl ester in Example 147A. The intermediate serving as the starting material for Example 147B is therefore 1-[5-hydroxy-3-(4-methoxy-phenyl)-4-phenyl-4,5-dihydro-isoxazol-5-yl]-cyclopropanecarboxylic acid ethyl ester instead of 1-[5-hydroxy-3-(4-methoxy-phenyl)-4-phenyl-4,5-dihydro-isoxazol-5-yl]-cyclopropanecarboxylic acid methyl ester.

Sources & evidence

ORD record
ord-68abcd1b9089481aac429d7611f95609
Source dataset
uspto-grants-2008_12
Patent number
US07470715B2

Reaction notes

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