Potassium Carbonate → HCID 86087963, compound

HRID 2378078Notes

Reaction equation

HRID 2378078 reaction equation
[CH2:1](Br)[C:2]#[C:3][CH3:4].[CH2:6]([O:8][C:9]([CH2:11][NH:12][C:13](=[N:21][C:22]#[N:23])[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10])[CH3:7].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:6]([O:8][C:9]([CH2:11][N:12]([CH2:1][C:2]#[C:3][CH3:4])[C:13](=[N:21][C:22]#[N:23])[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10])[CH3:7]

Participants

5

Reactant 3

HCID 11430Potassium Carbonate2×HCID 27568621-Bromo-2-butyne2×HCID 178472744HCID 178472744, compound

Product 1

HCID 86087963HCID 86087963, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

11 ml but-2-ynylbromide are added to a mixture of 30.2 g 1-ethoxycarbonylmethyl-3-cyano-2-phenyl-isourea and 20.0 g potassium carbonate in 200 ml acetone. After 1 d (day) stirring at ambient temperature a further 6.5 g potassium carbonate and 3.5 ml but-2-ynylbromide are added. After another 20 h at ambient temperature the solvent is removed and ethyl acetate is added. The organic phase is washed with water, dried over sodium sulphate and evaporated to dryness.

Workup

  1. additionare added
  2. customAfter another 20 h at ambient temperature the solvent is removed
  3. additionethyl acetate is added
  4. washThe organic phase is washed with water
  5. dry with materialdried over sodium sulphate
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-dbafb4395b1a4c53894edb9b0a890c34
Source dataset
uspto-grants-2008_12
Patent number
US07470716B2

Reaction notes

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