Phosphorus pentachloride → 4-Bromo-2-(methoxyimino)-3-oxobutanoyl chloride

HRID 2378148Notes

Reaction equation

HRID 2378148 reaction equation
[Br:1][CH2:2][C:3](=[O:11])[C:4](=[N:8][O:9][CH3:10])[C:5](O)=[O:6].P(Cl)(Cl)(Cl)(Cl)[Cl:13]>ClCCl>[Br:1][CH2:2][C:3](=[O:11])[C:4](=[N:8][O:9][CH3:10])[C:5]([Cl:13])=[O:6]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 536512154-Bromo-2-(methoxyimino)-3-oxobutanoic acid

Product 1

HCID 534266374-Bromo-2-(methoxyimino)-3-oxobutanoyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 30.20 gm (0.154 moles) of 4-bromo-2-methoxyimino-3-oxo-butyric acid in dichloromethane (230 ml) cooled to −10° C. under an atmosphere of nitrogen was added phosphorous pentachloride (28.10 gm; 0.134 moles) in portions and the solution of 4-bromo-2-methoxyimino-3-oxo butyric acid chloride (IV) in dichloromethane thus obtained is kept cooled to −10° C.

Sources & evidence

ORD record
ord-1bca734cb7d44401a91f34cda1f57d68
Source dataset
uspto-grants-2008_12
Patent number
US07470786B2

Reaction notes

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