HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine → 2-(4-Cyclohexyl-phenoxymethyl)-6-(2-methoxy-ethyl)-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine | HCID 66875140 | — |
| Reactant | Methyl 2-formyl-4-methoxybutanoate | HCID 86640234 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-(4-Cyclohexyl-phenoxymethyl)-6-(2-methoxy-ethyl)-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one | HCID 25071113 | — |
Reaction Steps
The title compound was prepared from (S) -5-(4-cyclohexyl-phenoxy methyl)-4,5-dihydro-oxazol-2-ylamine and 2-formyl-4-methoxy-butyric acid methyl ester employing the procedure described in Step2 of Example 87. [α]D25 −19.00 (c 0.5, CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642603B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-53f6c17374b540578c3d54747e6b8332 |
| Source note | uspto-grants-2014_02 |