3-Amino-1-propanol → HCID 43393146, compound

HRID 2378360Notes

Reaction equation

HRID 2378360 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]([OH:12])=O.[NH2:13][CH2:14][CH2:15][CH2:16][OH:17]>>[OH:17][CH2:16][CH2:15][CH2:14][NH:13][C:10]([C:2]1[S:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=1)=[O:12]

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 95864Benzo(b)thiophene-2-carboxylic acid

Product 1

HCID 43393146HCID 43393146, compoundYield 52.3%

Procedure

2-Benzothiophenecarboxylic acid (5.0 g, 28.05 mmol) and 3-amino-1-propanol (2.57 ml, 33.66 mmol) were coupled according to the procedure of Example 22 to provide 3.45 g (52.3% yield) of the desired product as an orange solid. Electrospray Mass Spec: m/z 235.9 (M+H)+.

Sources & evidence

ORD record
ord-1e43d137ecb54f66bf6d2445dd8a60f3
Source dataset
uspto-grants-2008_12
Patent number
US07470794B2

Reaction notes

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