Ethyl chloroformate → HCID 25071429, Verbindung

HRID 237841Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 237841
[CH:1]1([C:7]2[CH:20]=[CH:19][C:10]([O:11][CH2:12][C@H:13]3[O:17][C:16]([NH2:18])=[N:15][CH2:14]3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O:23][C:24](=O)[C:25]#[C:26][CH2:27][CH:28]([CH3:30])[CH3:29])C.CC(C)CC#C.ClC(OCC)=O>C(Cl)(Cl)Cl>[CH:1]1([C:7]2[CH:20]=[CH:19][C:10]([O:11][CH2:12][C@H:13]3[O:17][C:16]4=[N:18][C:24](=[O:23])[CH:25]=[C:26]([CH2:27][CH:28]([CH3:30])[CH3:29])[N:15]4[CH2:14]3)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Komponenten

6

Edukt 4

HCID 10928Ethyl chloroformateHCID 1389484-Methyl-1-pentyneHCID 12383857Ethyl 5-methylhex-2-ynoateHCID 66875140(S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine

Produkt 1

HCID 25071429HCID 25071429, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

The title compound was prepared from (S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine and 5-methyl-hex-2-ynoic acid ethyl ester (prepared from 4-methyl-pent-1-yne and ethyl chloroformate in accordance with the procedures of G. Cai et al., Tetrahedron, 2006, 5697-5708) employing the procedure described in Example 99. [α]D25 −13.93 (c 0.546, CHCl3)

Quellen und Nachweise

ORD-Eintrag
ord-30f515942dbd47d7907ecbe58fc56f55
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642603B2

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