HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl chloroformate → HCID 25071429, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 4-Methyl-1-pentyne | HCID 138948 | — |
| Reactant | Ethyl 5-methylhex-2-ynoate | HCID 12383857 | — |
| Reactant | (S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine | HCID 66875140 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 25071429 | HCID 25071429 | — |
Reaction Steps
The title compound was prepared from (S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine and 5-methyl-hex-2-ynoic acid ethyl ester (prepared from 4-methyl-pent-1-yne and ethyl chloroformate in accordance with the procedures of G. Cai et al., Tetrahedron, 2006, 5697-5708) employing the procedure described in Example 99. [α]D25 −13.93 (c 0.546, CHCl3)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642603B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-30f515942dbd47d7907ecbe58fc56f55 |
| Source note | uspto-grants-2014_02 |