HuagongsheHuagongshe Chemistry Print Report · For research reference only
Calcium Chloride → 5-Amino-2-cyano-3,4-dimethylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Calcium Chloride | HCID 5284359 | — |
| Reactant | 2-Cyano-3,4-dimethyl-5-nitropyridine | HCID 21875209 | — |
| Catalyst | Iron | HCID 23925 | — |
| Product | 5-Amino-2-cyano-3,4-dimethylpyridine | HCID 21875109 | 50% |
Reaction Steps
2-Cyano-3,4-dimethyl-5-nitropyridine (0.15 g, 0.85 mmol), calcium chloride (0.05 g, 0.42 mmol), and iron powder (0.44 g, 7.8 mmol, 325 Mesh) were reacted as described in example 772B. Purification of the crude product by silica gel chromatography using 1:1 ether/CH2Cl2 as the eluent gave compound 773B (0.054 g, 50%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07470797B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-ebc5759d41404fb8a5b30fff6969d9c4 |
| Source note | uspto-grants-2008_12 |