反应详情

2-Cyano-3,4-dimethyl-5-nitropyridine (0.15 g, 0.85 mmol), calcium chloride (0.05 g, 0.42 mmol), and iron powder (0.44 g, 7.8 mmol, 325 Mesh) were reacted as described in example 772B. Purification of the crude product by silica gel chromatography using 1:1 ether/CH2Cl2 as the eluent gave compound 773B (0.054 g, 50%) as a yellow solid.

1. customPurification of the crude product by silica gel chromatography