Methyl iodide → N-[4-chloro-2-methyl-3-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide

Temperature

2.5 °C

To a solution of N-(4-chloro-3-trifluoromethylphenyl)-2,2-dimethylpropionamide (2.29 g, 8.19 mmol) in anhydrous THF (25 mL) cooled to 0-5° C. was added a solution of 1.6 M n-butyllithium in hexanes (12.3 mL, 19.7 mmol), added slowly so that the reaction temperature was maintained below 5° C. The solution was stirred at 0-5° C. for 1.5 h. A solution of iodomethane (0.56 mL, 9.01 mmol) in petroleum ether (2 mL) was added over 20 min while maintaining the temperature below 5° C. The suspension was stirred at 0-5° C. for 1 h and diluted with water and ether. The aqueous layer was extracted with ether and the combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was chromatographed (silica gel), eluting with CH2Cl2 to afford compound 841B (1.60 g, 67%). MS (ES): m/z=294 [M+1]+.

1. additionadded slowly so that the reaction temperature
2. temperaturewas maintained below 5° C
3. temperaturewhile maintaining the temperature below 5° C
4. stirringThe suspension was stirred at 0-5° C. for 1 h
5. extractionThe aqueous layer was extracted with ether
6. washthe combined organic layers were washed with brine
7. dry with materialdried over MgSO4
8. filtrationfiltered
9. concentrationconcentrated in vacuo
10. customThe residue was chromatographed (silica gel)
11. washeluting with CH2Cl2

ORD record

ord-67ab90558d644c348316fc32985012bc

Source dataset

uspto-grants-2008_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07470797B2