反应详情

温度

80 °C

In a hydrogenation flask was added 2-(4-fluoro-benzoyl)-benzoic acid, propylene glycol monomethyl ether (1 L/mol) and Pd/C 10% wet (15 g/mol). Hydrogenation was performed at 50° C. over 18 hours. Thiophene (0.3 kg/mol) was added and the catalyst was filtered off. The filtrate was heated up to 80° C. and water (1.12 L/mol) was added at that temperature. The mixture was heated up to reflux, then cooled down to 25° C. and stirred at that temperature during 1 hour. The precipitate was filtered off, washed with water (1 L/mol) and dried at 50° C. during 18 hours. Active yield: 83%.

1. filtrationthe catalyst was filtered off
2. additionwater (1.12 L/mol) was added at that temperature
3. temperatureThe mixture was heated up
4. temperatureto reflux
5. temperaturecooled down to 25° C.
6. filtrationThe precipitate was filtered off
7. washwashed with water (1 L/mol)
8. customdried at 50° C. during 18 hours