HCID 86614979, compound → HCID 86614978, compound

HRID 2378546Notes

Reaction equation

HRID 2378546 reaction equation
C([O:8][C:9]1[C:14]([NH:15][C:16](=[O:21])[C:17]([F:20])([F:19])[F:18])=[CH:13][C:12]([CH2:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])=[CH:11][C:10]=1[C:28]1[CH:37]=[CH:36][C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=1)C1C=CC=CC=1>C(OCC)(=O)C.CO.[Pd]>[OH:8][C:9]1[C:14]([NH:15][C:16](=[O:21])[C:17]([F:18])([F:19])[F:20])=[CH:13][C:12]([CH2:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])=[CH:11][C:10]=1[C:28]1[CH:37]=[CH:36][C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=1

Participants

5

Reactant 1

HCID 86614979HCID 86614979, compound

Product 1

HCID 86614978HCID 86614978, compoundYield 90.8%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of Intermediate 52 (3.20 g) in a mixture of ethyl acetate (50 ml) and methanol (25 ml) was added with 10% palladium/carbon (98 mg), and stirred at room temperature for 2 hours under hydrogen atmosphere. The reaction mixture was filtered, and the solvent of the filtrate was evaporated under reduced pressure to obtain the title compound (Intermediate 53, 2.39 g).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent of the filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-53c6b62f8eb74064b36f5d453336a878
Source dataset
uspto-grants-2008_12
Patent number
US07470807B2

Reaction notes

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