Sodium Hydroxide → HCID 68742074, compound

HRID 2378550Notes

Reaction equation

HRID 2378550 reaction equation
FC1C=C(CCC(O)=O)C=CC=1OC.C([O:18][C:19]1[CH:20]=[C:21]([CH2:41][CH2:42][C:43]([O:45]CC)=[O:44])[CH:22]=[C:23]([C:31]2[CH:40]=[CH:39][C:38]3[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=3)[CH:32]=2)[C:24]=1[O:25][CH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1)(=O)C.[OH-].[Na+]>>[CH:26]1([O:25][C:24]2[C:23]([C:31]3[CH:40]=[CH:39][C:38]4[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=4)[CH:32]=3)=[CH:22][C:21]([CH2:41][CH2:42][C:43]([OH:45])=[O:44])=[CH:20][C:19]=2[OH:18])[CH2:27][CH2:28][CH2:29][CH2:30]1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 30179663-(3-Fluoro-4-methoxyphenyl)propionic acidHCID 68741546HCID 68741546, compound

Product 1

HCID 68742074HCID 68742074, compoundYield 109.7%

Procedure

According to the procedure described in the synthesis method of Intermediate 9 provided that the reaction was carried out for 2 hours, Intermediate 58 (146 mg) and 2 N aqueous sodium hydroxide (0.35 ml) were reacted and treated to obtain the title compound (Compound No. T-2, 135 mg).

Workup

  1. customprovided that the reaction
  2. additiontreated

Sources & evidence

ORD record
ord-b4eef3d544c548808ae9cd84744541c2
Source dataset
uspto-grants-2008_12
Patent number
US07470807B2

Reaction notes

Loading…