反应详情

温度

80 °C

A solution of Intermediate 76 (202 mg) in ethanol (8 ml) was added with 5 N aqueous hydrochloric acid (1.5 ml), and stirred at 80° C. for 18.5 hours. The reaction mixture was concentrated under reduced pressure, and added with water (20 ml) and ethyl acetate (80 ml) for extraction. The organic layer was washed with saturated brine and dried, and then the solvent was evaporated under reduced pressure. The residue was added with 2 N aqueous sodium hydroxide (1.0 ml), reacted and treated according to the procedure described in the synthesis method of Intermediate 9 provided that the reaction was carried out for 2 hours to obtain the title compound (Compound No. V-89, 250 mg).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionadded with water (20 ml) and ethyl acetate (80 ml) for extraction
3. washThe organic layer was washed with saturated brine
4. customdried
5. customthe solvent was evaporated under reduced pressure
6. additionThe residue was added with 2 N aqueous sodium hydroxide (1.0 ml)
7. customreacted
8. additiontreated
9. customprovided that the reaction
10. waitwas carried out for 2 hours