Imidazole → 3-Bromo-4-(1H-imidazol-1-YL)benzaldehyde

HRID 2378571Notes

Reaction equation

HRID 2378571 reaction equation
C(Cl)(Cl)Cl.[Br:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=1F)[CH:9]=[O:10].C(=O)([O-])[O-].[K+].[K+].[NH:21]1[CH:25]=[CH:24][N:23]=[CH:22]1>CO>[Br:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=1[N:21]1[CH:25]=[CH:24][N:23]=[CH:22]1)[CH:9]=[O:10]

Participants

6

Reactant 4

HCID 795ImidazoleHCID 6212ChloroformHCID 11430Potassium CarbonateHCID 1736043-Bromo-4-fluorobenzaldehyde

Product 1

HCID 534295903-Bromo-4-(1H-imidazol-1-YL)benzaldehydeYield 64%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to the procedure described in the synthesis method of Intermediate Int. n-26 (Synthesis method NG) provided that the reaction was performed for 20 hours, and the column chromatography was performed with chloroform:methanol=100:1, 3-bromo-4-fluorobenzaldehyde (1.246 g, TCI), potassium carbonate (825.1 mg) and imidazole (444 mg, TCI) were reacted and treated to obtain the title compound (Intermediate Int. n-32, 986.1 mg).

Workup

  1. customdescribed in the synthesis method of Intermediate Int
  2. customn-26 (Synthesis method NG)
  3. customprovided that the reaction
  4. additiontreated

Sources & evidence

ORD record
ord-cb2af22aaeee432ebc6b209939b7ee4c
Source dataset
uspto-grants-2008_12
Patent number
US07470807B2

Reaction notes

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