Triethylamine → HCID 59732023, compound

HRID 2378637Notes

Reaction equation

HRID 2378637 reaction equation
C(N([CH2:6][CH3:7])CC)C.C([O:10][C:11](=O)[CH2:12][N:13](C1C=CC=CC=1)[C:14](=[O:29])[NH:15][CH:16]1[CH2:21][CH2:20][N:19]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:18][CH2:17]1)C>C(O)C>[O:29]=[C:14]1[NH:13][CH:12]([C:7]2[CH:6]=[CH:18][CH:17]=[CH:16][CH:21]=2)[C:11](=[O:10])[N:15]1[CH:16]1[CH2:21][CH2:20][N:19]([C:22]([O:24][C:25]([CH3:28])([CH3:26])[CH3:27])=[O:23])[CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 59731914HCID 59731914, compound

Product 1

HCID 59732023HCID 59732023, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Triethylamine (200 μL, 1.43 mmol) was added to a solution of tert-butyl 4-(3-(2-ethoxy-2-oxoethyl)-3-phenylureido)piperidine-1-carboxylate (90 mg, 0.22 mmol) in ethanol (1.8 mL). Reaction was held at 60° C. with stirring for 3 hours. Reaction mixture was concentrated in vacuo. Reside was treated with dichloromethane (20 mL) and then concentrated in vacuo. Title compound was obtained as white solid in 81% yield. MS m/e (M−C4H8+H)+=304.2.

Workup

  1. customReaction
  2. customwas held at 60° C.
  3. customReaction mixture
  4. concentrationwas concentrated in vacuo
  5. additionReside was treated with dichloromethane (20 mL)
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-c52e1250dff84a21812110b9d1dfba1c
Source dataset
uspto-grants-2008_12
Patent number
US07470679B2

Reaction notes

Loading…