反应详情

Concentrated hydrochloric acid (8.0 mL, 97 mmol) was added with stirring to a mixture of tert-butyl 4-(1-hydroxy-3-methoxy-3-oxo-1-(4-pivalamidopyridin-3-yl)propan-2-yl)piperidine-1-carboxylate (1.2 g, 2.6 mmol) and water (24 mL). Reaction was heated to reflux and held for 14 hours. Mixture was concentrated in vacuo. Residue was treated with acetonitrile (70 mL) and then concentrated in vacuo. Residue was crystallized from ethanol. Title compound was obtained as white solid in 77% yield. (M+H)+=230.1.

1. customReaction
2. temperaturewas heated
3. temperatureto reflux
4. concentrationMixture was concentrated in vacuo
5. additionResidue was treated with acetonitrile (70 mL)
6. concentrationconcentrated in vacuo
7. customResidue was crystallized from ethanol