Sodium Hydroxide → HCID 67089882, compound

HRID 2378732Notes

Reaction equation

HRID 2378732 reaction equation
C([O:3][C:4]([CH2:6][CH2:7][NH:8][C:9](=[O:27])[C:10]1[CH:15]=[CH:14][C:13](/[CH:16]=[CH:17]/[C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][N:19]=2)=[CH:12][CH:11]=1)=[O:5])C.[OH-].[Na+]>C1COCC1>[C:4]([CH2:6][CH2:7][NH:8][C:9](=[O:27])[C:10]1[CH:15]=[CH:14][C:13](/[CH:16]=[CH:17]/[C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][N:19]=2)=[CH:12][CH:11]=1)([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67090441HCID 67090441, compound

Product 1

HCID 67089882HCID 67089882, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compound 79 (1.0 g, 2.75 mmol) was dissolved in THF (30 mL), and the solution was added with 2 mol/L aqueous sodium hydroxide solution (20 mL), followed by neutralization and filtration to obtain (E)-N-(2-carboxyethyl)-4-[2-(1H-indazol-3-yl)vinyl]benzamide (710 mg, 77%).

Workup

  1. filtrationfollowed by neutralization and filtration

Sources & evidence

ORD record
ord-b7747c45a7ac4c819067cad6b745e4cd
Source dataset
uspto-grants-2008_12
Patent number
US07470717B2

Reaction notes

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