反应详情

温度

0 °C

To a stirred mixture of diphenyl-phosphinic acid 4-cyclohexyl-benzyl ester (1 g, 2.56 mmol) and 1.22 ml (7.69 mmol) of allyltrimethylsilane in 12 ml of dry dimethoxy-ethane at 0° C. was added 0.46 ml of trimethylsilyltriflate. The mixture was stirred at 0° C. for 1 h, poured into saturated bicarbonate, extracted with ethyl acetate, washed with water, dried (sodium sulfate) filtered and concentrated. The material was purified by chromatography on silica gel, eluting with ethyl acetate/heptane to provide 0.45 g of the title compound.

1. extractionextracted with ethyl acetate
2. washwashed with water
3. dry with materialdried (sodium sulfate)
4. filtrationfiltered
5. concentrationconcentrated
6. customThe material was purified by chromatography on silica gel
7. washeluting with ethyl acetate/heptane