反应详情

(R)-3-(7-chloro-4-(chloromethyl)-1H-indazol-5-yl)-1-methoxy-1-oxopropan-2-yl benzoate (6.80 g, 16.7 mmol) in acetonitrile (70.0 ml, 1340 mmol) was added 2,2,2-trifluoroethylamine (8.27 g, 84 mmol). After 20 min, potassium carbonate (2.308 g, 16.70 mmol) was added and the reaction mixture was refluxed for 2 h. The solvent was evaporated and the crude product was dissolved in a mixture of dichloromethane and chloroform. A thick emulsion formed and addition of methanol provided a clear organic phase. The organic layer was dried (Na2SO4), the solvent was removed and the crude product was used as such for the next step. MS (ESI) 470 (M+H); Rf=1.56.

1. temperaturethe reaction mixture was refluxed for 2 h
2. customThe solvent was evaporated
3. dissolutionthe crude product was dissolved in a mixture of dichloromethane and chloroform
4. customA thick emulsion formed
5. customprovided a clear organic phase
6. dry with materialThe organic layer was dried (Na2SO4)
7. customthe solvent was removed