Hydrochloric Acid → HCID 68967208, 화합물

HRID 2378945노트

반응식

HRID 2378945 반응식
[C:1]([C:3]1[NH:4][C:5](=[O:21])[N:6]([CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[CH:7]=1)#[N:2].[ClH:22].O1CCOCC1>C(OCC)(=O)C>[ClH:22].[O:21]=[C:5]1[NH:4][C:3]([C:1]#[N:2])=[CH:7][N:6]1[CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59006363Tert-butyl 4-(4-cyano-2-oxo-2,3-dihydroimidazol-1-yl)piperidine-1-carboxylate

생성물 1

HCID 68967208HCID 68967208, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

tert-Butyl 4-(4-cyano-2-oxo-2,3-dihydroimidazol-1-yl)piperidine-1-carboxylate (45 mg, 0.154 mmol) was dissolved in ethyl acetate (5.0 mL). 4M Hydrogen chloride in 1,4-dioxane (10 mL, 40 mmol) was added to the mixture. Reaction was stirred at room temperature for 18 hours. Liquids were decanted off. Remaining solids were dissolved in methanol and then transferred to a smaller flask. Material was concentrated by roto-vap. Residue was treated with dichloromethane and then concentrated to dryness. Title compound was obtained as yellow solid in quantitative yield. MS (M+H)+=193.0.

후처리

  1. customReaction
  2. customLiquids were decanted off
  3. dissolutionRemaining solids were dissolved in methanol
  4. customtransferred to a smaller flask
  5. concentrationMaterial was concentrated by roto-vap
  6. additionResidue was treated with dichloromethane
  7. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-bd4a9f7913564d538f3204c1881c5481
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07470680B2

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