反应详情

tert-Butyl 4-(4-cyano-2-oxo-2,3-dihydroimidazol-1-yl)piperidine-1-carboxylate (45 mg, 0.154 mmol) was dissolved in ethyl acetate (5.0 mL). 4M Hydrogen chloride in 1,4-dioxane (10 mL, 40 mmol) was added to the mixture. Reaction was stirred at room temperature for 18 hours. Liquids were decanted off. Remaining solids were dissolved in methanol and then transferred to a smaller flask. Material was concentrated by roto-vap. Residue was treated with dichloromethane and then concentrated to dryness. Title compound was obtained as yellow solid in quantitative yield. MS (M+H)+=193.0.

1. customReaction
2. customLiquids were decanted off
3. dissolutionRemaining solids were dissolved in methanol
4. customtransferred to a smaller flask
5. concentrationMaterial was concentrated by roto-vap
6. additionResidue was treated with dichloromethane
7. concentrationconcentrated to dryness