反应详情

温度

70 °C

0.8 g of 4-trifluoromethyl-3-pyridine carboxamide was dissolved in 7 ml of acetic acid. Then, 0.72 g of a 30% hydrogen peroxide aqueous solution was gradually dropwise added thereto. After completion of the dropwise addition, the reaction solution was heated to 70° C. and stirred for 8 hours at this temperature. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue thereby obtained was washed with n-hexane to obtain 0.6 g of 4-trifluoromethyl-3-pyridine carboxamide 1-oxide (melting point: 198.8° C.) as the desired product.

1. additionAfter completion of the dropwise addition
2. customAfter completion of the reaction
3. distillationthe solvent was distilled off under reduced pressure
4. customThe residue thereby obtained
5. washwas washed with n-hexane