Hydrogen Peroxide → HCID 15766288, compound

HRID 2379044Notes

Reaction equation

HRID 2379044 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[C:9]([NH2:11])=[O:10].[OH:14]O>C(O)(=O)C>[F:13][C:2]([F:1])([F:12])[C:3]1[CH:8]=[CH:7][N+:6]([O-:14])=[CH:5][C:4]=1[C:9]([NH2:11])=[O:10]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 27826434-Trifluoromethylnicotinamide

Product 1

HCID 15766288HCID 15766288, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
70 °C

Procedure

0.8 g of 4-trifluoromethyl-3-pyridine carboxamide was dissolved in 7 ml of acetic acid. Then, 0.72 g of a 30% hydrogen peroxide aqueous solution was gradually dropwise added thereto. After completion of the dropwise addition, the reaction solution was heated to 70° C. and stirred for 8 hours at this temperature. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue thereby obtained was washed with n-hexane to obtain 0.6 g of 4-trifluoromethyl-3-pyridine carboxamide 1-oxide (melting point: 198.8° C.) as the desired product.

Workup

  1. additionAfter completion of the dropwise addition
  2. customAfter completion of the reaction
  3. distillationthe solvent was distilled off under reduced pressure
  4. customThe residue thereby obtained
  5. washwas washed with n-hexane

Sources & evidence

ORD record
ord-9ef1bc7d7c344a3a991d240e3d1e40ed
Source dataset
uspto-grants-1994_11
Patent number
US05360806

Reaction notes

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