Methanol → HCID 18957859, compound

HRID 2379074Notes

Reaction equation

HRID 2379074 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8](=[O:11])[N:7]([CH2:12][CH2:13][CH2:14][NH:15][C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)=[O:17])[CH:6]=1)=[O:4].CO.C(=O)([O-])[O-].[Na+].[Na+]>O>[N:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:16]([NH:15][CH2:14][CH2:13][CH2:12][N:7]1[C:8](=[O:11])[CH:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[CH:6]1)=[O:17]

Participants

5

Reactant 3

HCID 887MethanolHCID 10340Sodium CarbonateHCID 53711807HCID 53711807, compound

Product 1

HCID 18957859HCID 18957859, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1,6-dihydro-1-[3-(2-pyridinylcarbonylamino)propyl]-6-oxo-3-pyridinecarboxylic acid methyl ester (0.260 g, 0.83 retool) was hydrolysed in a mixture consisting of methanol (1.0 ml), water (1.0 ml), and 15% aqueous sodium carbonate (2.0 ml) at 60° for 1.5 hours. The solution was filtered and acidified (to pH 5.5 with acetic acid). The precipitated product was recovered by filtration, washed with water, and dried, MP: 180°-182° C.

Workup

  1. filtrationThe solution was filtered
  2. filtrationThe precipitated product was recovered by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-5164ad3f18034151bd876494970f7c30
Source dataset
uspto-grants-1994_11
Patent number
US05360808

Reaction notes

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