Acetic Acid → HCID 18957857, compound

HRID 2379075Notes

Reaction equation

HRID 2379075 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8](=[O:11])[N:7]([CH2:12][CH2:13][NH:14][C:15]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)=[O:16])[CH:6]=1)=[O:4].O.C(=O)([O-])[O-].[Na+].[Na+].C(O)(=O)C>CO>[N:19]1[CH:20]=[CH:21][CH:22]=[C:17]([C:15]([NH:14][CH2:13][CH2:12][N:7]2[C:8](=[O:11])[CH:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[CH:6]2)=[O:16])[CH:18]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 962WaterHCID 10340Sodium CarbonateHCID 54154763HCID 54154763, compound

Product 1

HCID 18957857HCID 18957857, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1,6-dihydro-1-[2-(3-pyridinylcarbonylamino)ethyl]-6-oxo-3-pyridinecarboxylic acid methyl ester (0.39 g, 1.3 mmol) was hydrolysed in a mixture of methanol (3.9 ml), water (3.9 ml), and 15% aqueous sodium carbonate (3.9 ml) at 65°-70° C. for 1.5 hours. The solution was acidified (to pH 5.5 with acetic acid). The precipitated product was recovered by filtration, washed with water, and dried, MP: >295 ° C.

Workup

  1. filtrationThe precipitated product was recovered by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-418792ea65064e67a0eeda17ed0da5eb
Source dataset
uspto-grants-1994_11
Patent number
US05360808

Reaction notes

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