Acetic Acid → HCID 18957857, compound

Participants

Reaction Steps

1,6-dihydro-1-[2-(3-pyridinylcarbonylamino)ethyl]-6-oxo-3-pyridinecarboxylic acid methyl ester (0.39 g, 1.3 mmol) was hydrolysed in a mixture of methanol (3.9 ml), water (3.9 ml), and 15% aqueous sodium carbonate (3.9 ml) at 65°-70° C. for 1.5 hours. The solution was acidified (to pH 5.5 with acetic acid). The precipitated product was recovered by filtration, washed with water, and dried, MP: >295 ° C.

Provenance & Evidence