Methanol → HCID 18957855, compound

HRID 2379076Notes

Reaction equation

HRID 2379076 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8](=[O:11])[N:7]([CH2:12][CH2:13][CH2:14][NH:15][C:16]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)=[O:17])[CH:6]=1)=[O:4].CO.O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(=O)C>[N:20]1[CH:21]=[CH:22][CH:23]=[C:18]([C:16]([NH:15][CH2:14][CH2:13][CH2:12][N:7]2[C:8](=[O:11])[CH:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[CH:6]2)=[O:17])[CH:19]=1

Participants

6

Reactant 4

HCID 887MethanolHCID 962WaterHCID 10340Sodium CarbonateHCID 53776956HCID 53776956, compound

Product 1

HCID 18957855HCID 18957855, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1,6-dihydro-1-[3-(3-pyridinylcarbonylamino)propyl]-6-oxo-3-pyridinecarboxylic acid methyl ester (0.18 g, 0.57 mmol) was hydrolysed in a mixture consisting of methanol (0.7 ml), water (0.7 ml), and 15% aqueous sodium carbonate (0.7 ml) at 60° C. for 1.3 hours. The solution was acidified (to pH 5.5 with acetic acid). The precipitated product was recovered by filtration, washed with water, and dried, MP: 218°-220° C.

Workup

  1. filtrationThe precipitated product was recovered by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-19d7ab7a1e8344bebb7e8596e44764f5
Source dataset
uspto-grants-1994_11
Patent number
US05360808

Reaction notes

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