Methanol → HCID 18957858, compound

HRID 2379077Notes

Reaction equation

HRID 2379077 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8](=[O:11])[N:7]([CH2:12][CH2:13][NH:14][C:15]([C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)=[O:16])[CH:6]=1)=[O:4].CO.O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(=O)C>[N:20]1[CH:21]=[CH:22][C:17]([C:15]([NH:14][CH2:13][CH2:12][N:7]2[C:8](=[O:11])[CH:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[CH:6]2)=[O:16])=[CH:18][CH:19]=1

Participants

6

Reactant 4

HCID 887MethanolHCID 962WaterHCID 10340Sodium CarbonateHCID 53878817HCID 53878817, compound

Product 1

HCID 18957858HCID 18957858, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1,6-dihydro-1-[2-(4-pyridinylcarbonylamino)ethyl]-6-oxo-3-pyridinecarboxylic acid methyl ester (0.600 g, 2.0 mmol) was hydrolysed in a mixture consisting of methanol (4.0 ml), water (0.7 ml), and 15% aqueous sodium carbonate (6.0 ml) at 75°-80° C. for 1.25 hours. The solution was acidified (to pH 5.5 with acetic acid). The precipitated product was recovered by filtration, washed with water, and dried, MP: >300° C.

Workup

  1. filtrationThe precipitated product was recovered by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-673f07c924db4c5e924fc754adb02bf2
Source dataset
uspto-grants-1994_11
Patent number
US05360808

Reaction notes

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