Methanol → HCID 18957858, compound

Participants

Reaction Steps

1,6-dihydro-1-[2-(4-pyridinylcarbonylamino)ethyl]-6-oxo-3-pyridinecarboxylic acid methyl ester (0.600 g, 2.0 mmol) was hydrolysed in a mixture consisting of methanol (4.0 ml), water (0.7 ml), and 15% aqueous sodium carbonate (6.0 ml) at 75°-80° C. for 1.25 hours. The solution was acidified (to pH 5.5 with acetic acid). The precipitated product was recovered by filtration, washed with water, and dried, MP: >300° C.

Provenance & Evidence