Boron tribromide → HCID 18957925, compound

HRID 2379125Notes

Reaction equation

HRID 2379125 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:13]3[CH:14]=[CH:15][C:16]([C:18]([F:21])([F:20])[F:19])=[CH:17][C:12]=3[N:11]=[CH:10]2)[CH:6]=[CH:7][CH:8]=1.B(Br)(Br)Br>C(Cl)Cl>[OH:2][C:3]1[CH:4]=[C:5]([N:9]2[C:13]3[CH:14]=[CH:15][C:16]([C:18]([F:21])([F:20])[F:19])=[CH:17][C:12]=3[N:11]=[CH:10]2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 18957924HCID 18957924, compound

Product 1

HCID 18957925HCID 18957925, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To an ice cooled solution of 1-(3-methoxyphenyl)-5-trifluoromethylbenzimidazole (79a)(0.50 g, 1.71 mmol) under nitrogen in dry methylene chloride (20 ml) was added boron tribromide (2.6 ml of an 1M solution in methylene chloride). The ice bath was removed and the reaction mixture was stirred for two days at room temperature, Dilution with water and extractive workup with ether was followed by chromatography. Yield: 0.29 g, 1.04 mmol, 61%. mp 168°-170° C.

Workup

  1. customThe ice bath was removed

Sources & evidence

ORD record
ord-a496fcb609934193bf30eeaa225e5b55
Source dataset
uspto-grants-1994_11
Patent number
US05360809

Reaction notes

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