Boron tribromide → HCID 18957925, compound

Participants

Reaction Steps

To an ice cooled solution of 1-(3-methoxyphenyl)-5-trifluoromethylbenzimidazole (79a)(0.50 g, 1.71 mmol) under nitrogen in dry methylene chloride (20 ml) was added boron tribromide (2.6 ml of an 1M solution in methylene chloride). The ice bath was removed and the reaction mixture was stirred for two days at room temperature, Dilution with water and extractive workup with ether was followed by chromatography. Yield: 0.29 g, 1.04 mmol, 61%. mp 168°-170° C.

Provenance & Evidence