Water → HCID 15616312, compound

HRID 2379133Notes

Reaction equation

HRID 2379133 reaction equation
[BH4-].[Na+].[CH:3]([C:5]1[N:6]=[CH:7][N:8]([S:13]([N:16]([CH3:18])[CH3:17])(=[O:15])=[O:14])[C:9]=1[CH2:10][CH2:11][CH3:12])=[O:4].O>C(O)C>[OH:4][CH2:3][C:5]1[N:6]=[CH:7][N:8]([S:13]([N:16]([CH3:17])[CH3:18])(=[O:14])=[O:15])[C:9]=1[CH2:10][CH2:11][CH3:12]

Participants

5

Reactant 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 15616311HCID 15616311, compound

Product 1

HCID 15616312HCID 15616312, compoundYield 93.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sodium borohydride (139 mg) was added to a stirred solution of 4-formyl-N,N-dimethyl-5-propyl-1H-imidazole-1-sulphonamide (450 mg) in absolute ethanol (5 ml) under nitrogen. After 3 h the mixture was poured into water (30 ml) and extracted with dichloromethane (3×15 ml). The combined, dried organic extracts were evaporated to give a solid (425 mg) which was triturated with ether (2×10 ml) to give the title compound (350 mg), m.p. 86°-88°.

Workup

  1. extractionextracted with dichloromethane (3×15 ml)
  2. customdried organic extracts were evaporated

Sources & evidence

ORD record
ord-8e69d1e70eab42599bf0c9d6fbb9b998
Source dataset
uspto-grants-1994_11
Patent number
US05360800

Reaction notes

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