反应详情

5'-Amino-2'-fluoroacetophenone (28 g) was dissolved in a mixture of 100 ml of ethyl acetate and 15.9 g of pyridine, a solution of 23 g of methanesulfonyl chloride in 50 ml of ethyl acetate was added with ice-cooling and stirring and the mixture was made to react at room temperature for 3 hours. The reaction mixture was washed with water, dried, the solvent was evaporated therefrom and the residue was purified by silica gel column chromatography (eluting with chloroform) to give 33.7 g of 3'-acetyl-4'-fluoromethanesulfonanilide, m.p. 120°-123° C.

1. temperaturecooling
2. customto react at room temperature for 3 hours
3. washThe reaction mixture was washed with water
4. customdried
5. customthe solvent was evaporated
6. customthe residue was purified by silica gel column chromatography (eluting with chloroform)