HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-5-nitrobenzoic acid → 5-Amino-2-fluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-5-nitrobenzoic acid | HCID 280997 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Amino-2-fluorobenzoic acid | HCID 2735910 | 83.5% |
Reaction Steps
2-Fluoro-5-nitrobenzoic acid (60 g) was suspended in 300 ml of methanol, 6.0 g of 5% palladium-carbon was added thereto and the mixture was reduced at 40 ° C. with hydrogen pressure of 6.5 atm. The catalyst was removed, the solvent was evaporated and the crystals separated out therefrom were filtered to give 42 g of 5-amino-2-fluorobenzoic acid, m.p. 189°-192° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05360822 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-65ea34e2c72948069c93eb5351e35c19 |
| Source note | uspto-grants-1994_11 |