Piperidine → HCID 54284523, compound

HRID 2379402Notes

Reaction equation

HRID 2379402 reaction equation
[NH:1]1[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[S:3].[OH:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([N+:18]([O-:20])=[O:19])[C:16]=1[OH:17])[CH:12]=O.N1CCCCC1>C(O)(=O)C>[OH:8][C:9]1[CH:10]=[C:11]([CH:12]=[C:7]2[C:5](=[O:6])[NH:4][C:2](=[S:3])[NH:1]2)[CH:14]=[C:15]([N+:18]([O-:20])=[O:19])[C:16]=1[OH:17]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 12740302-ThiohydantoinHCID 57489573,4-Dihydroxy-5-nitrobenzaldehyde

Product 1

HCID 54284523HCID 54284523, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

A solution containing 2.9 g (0.025 mol) of 2-thiohydantoin, 4.6 g (0.025 mol) of 3,4-dihydroxy-5-nitrobenzaldehyde and 0.25 ml of piperidine in 50 ml of acetic acid was heated for 7-8 h at 100° C. The crystalls were filtered and washed with 2-propanol. Yield 5.0 g (71%), mp>350° C. (decom.).

Workup

  1. filtrationThe crystalls were filtered
  2. washwashed with 2-propanol

Sources & evidence

ORD record
ord-fb6bd4eb9e2a483b92ad8e120d9d9539
Source dataset
uspto-grants-1994_11
Patent number
US05362733

Reaction notes

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