Thiazolidinedione → HCID 54308417, compound

HRID 2379404Notes

Reaction equation

HRID 2379404 reaction equation
[S:1]1[CH2:5][C:4](=[O:6])[NH:3][C:2]1=[O:7].[OH:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([N+:18]([O-:20])=[O:19])[C:16]=1[OH:17])[CH:12]=O.N1CCCCC1>C(O)(=O)C>[OH:8][C:9]1[CH:10]=[C:11]([CH:12]=[C:5]2[S:1][C:2](=[O:7])[NH:3][C:4]2=[O:6])[CH:14]=[C:15]([N+:18]([O-:20])=[O:19])[C:16]=1[OH:17]

Participants

5

Reactant 3

HCID 5437ThiazolidinedioneHCID 8082PiperidineHCID 57489573,4-Dihydroxy-5-nitrobenzaldehyde

Product 1

HCID 54308417HCID 54308417, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

A solution containing 0.59 g (0.005 mol) of thiazolidine-2,4-dione, 0.92 g (0.005 mol) of 3,4-dihydroxy-5-nitrobenzaldehyde and 0.05 ml of piperidine in 5 ml of acetic acid was heated for 7-8 h at 80° C. The crystalls were filtered and washed with ethanol. Yield 1.0 g (72%), mp 295°-298° C.

Workup

  1. filtrationThe crystalls were filtered
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-77712bcf64944b6aa74fb94e892721b6
Source dataset
uspto-grants-1994_11
Patent number
US05362733

Reaction notes

Loading…