Hydrochloric Acid → HCID 54443434, compound

HRID 2379453Notes

Reaction equation

HRID 2379453 reaction equation
C([O:4][C:5]1[C:18]2[C:17](=[O:19])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][C:15]=3[O:20]C(=O)C)[C:10](=[O:24])[C:9]=2[CH:8]=[C:7]([C:25]([OH:27])=O)[CH:6]=1)(=O)C.Cl>C(O)CCC>[CH2:5]([O:4][C:25]([C:7]1[CH:6]=[C:5]([OH:4])[C:18]2[C:17](=[O:19])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][C:15]=3[OH:20])[C:10](=[O:24])[C:9]=2[CH:8]=1)=[O:27])[CH2:6][CH2:7][CH3:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 26248Diacerein

Product 1

HCID 54443434HCID 54443434, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

7.4 g (0.02 mole) of 4,5-bis(acetoxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid are dissolved in 150 ml of butanol. Gaseous HCl is bubbled through the obtained solution until saturation. The reaction mixture is left to react for half an hour at room temperature, then it is heated to 60°-70° C. for 3 hours, while continuing HCl bubbling. The desired product precipitates, which is cooled, filtered and crystallized from ethyl acetate.

Workup

  1. customGaseous HCl is bubbled through the obtained solution until saturation
  2. waitThe reaction mixture is left
  3. customto react for half an hour at room temperature
  4. temperatureit is heated to 60°-70° C. for 3 hours
  5. customThe desired product precipitates
  6. temperaturewhich is cooled
  7. filtrationfiltered
  8. customcrystallized from ethyl acetate

Sources & evidence

ORD record
ord-9eaf853dcfb44e8d9cc0d89893c06b94
Source dataset
uspto-grants-1994_11
Patent number
US05362750

Reaction notes

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