Potassium Hydroxide → HCID 10755357, compound

HRID 2379471Notes

Reaction equation

HRID 2379471 reaction equation
[OH-].[K+].[CH2:3]([N:15]1[N:19]=[N:18][C:17]([C:20]([O:22]CC)=[O:21])=[N:16]1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]>C(O)C>[CH2:3]([N:15]1[N:19]=[N:18][C:17]([C:20]([OH:22])=[O:21])=[N:16]1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 10543007HCID 10543007, compound

Product 1

HCID 10755357HCID 10755357, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a room temperature, stirred solution of potassium hydroxide (1.97 g, 0.035 mol) in absolute ethanol (280 mL) was added in one portion 2-dodecyl-2H-tetrazole-5-carboxylic acid, ethyl ester (8.7 g, 0.028 mol), and the mixture was stirred for 28 hours. A white precipitate formed. The solids were filtered off, washed with ethanol, and partitioned between ethyl acetate and 10% hydrochloric acid. The organic layer was washed with saturated sodium chloride, dried (MgSO4), and rotoevaporated to a white solid, yield 7.74 g (98%), mp=122°-124° C.

Workup

  1. customA white precipitate formed
  2. filtrationThe solids were filtered off
  3. washwashed with ethanol
  4. custompartitioned between ethyl acetate and 10% hydrochloric acid
  5. washThe organic layer was washed with saturated sodium chloride
  6. dry with materialdried (MgSO4)

Sources & evidence

ORD record
ord-4c74023465d24835875e6376eb9352c2
Source dataset
uspto-grants-1994_11
Patent number
US05362744

Reaction notes

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